Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. When you have suffered a pregnancy loss or are in the process of having a miscarriage, you may be wondering what caused losing and worry about whether it’ll happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is crucial that it have the right level of chromosome material; missing or extra material during conception or within an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of all first trimester miscarriages are due to chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother ages.

Nearly all women who experience a miscarriage go on to get a healthy pregnancy rather than miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas previously the miscarriage would have appeared to be just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many different types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For that reason requirement, tissue that’s passed at home is frequently unable to be tested with this method. About 20% or even more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it could be maternal cell contamination (MCC) in which the result actually originates from testing the mother’s cells present in the pregnancy tissue instead of the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you are more prone to receive results and the results are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting an example of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

If a chromosome abnormality is identified, the kind of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. Quite often, chromosome abnormalities within an embryo or fetus aren’t inherited and have a minimal chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason for a pregnancy loss might help a couple start the emotional healing up process, moving past the question of “Why did this eventually me?”.

Chromosome testing can be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. pregnancy For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having an effective healthy pregnancy.